Peran Multivitamin terhadap Pertumbuhan dan Kesehatan Rambut: Literature Review

Authors

  • Nabila Ayu Imani Universitas Yarsi
  • Hapsari Triandriyani Rumah Sakit Umum Daerah Pasar Rebo
  • Hadi Firmansyah S Universitas Yarsi

DOI:

https://doi.org/10.55606/klinik.v5i1.5699

Keywords:

Alopecia, Hair Growth, Multivitamin, Nutrition, Supplementation

Abstract

Hair health is influenced by genetic, hormonal, environmental, and nutritional factors. Hair follicles have high metabolic activity that depends on adequate macro- and micronutrient supply. In recent years, multivitamin use has increased as a strategy to maintain hair health; however, its effectiveness and the risk of over-supplementation remain debated. This paper is a literature review of scientific articles, randomized controlled trials (RCTs), systematic reviews, and meta-analyses published within the last five years. Literature searches were conducted through PubMed, ScienceDirect, and Google Scholar using the keywords hair growth, multivitamin, nutrition, alopecia, supplementation. Macronutrients such as proteins (cysteine, methionine) and essential fatty acids play crucial roles in keratinization and follicular integrity. Micronutrients such as B-complex vitamins, vitamins D, A, C, and E, and minerals like zinc, iron, and selenium act as metabolic cofactors and antioxidants. Clinical evidence shows that multivitamin supplementation improves hair density and quality in individuals with suboptimal nutritional status, although excessive intake of vitamin A and selenium may trigger alopecia. Multivitamins are a promising adjunct therapy to support hair growth and health, especially in individuals with nutritional deficiencies. Their use should be rational, well-measured, and evidence-based to ensure optimal benefits while minimizing the risk of toxicity.

References

Ahmed, A., Sharma, D., & Ungar, B. (2025). Impact of nutraceutical supplements on hair growth in non-scarring alopecia: A systematic review and meta-analysis. Archives of Dermatological Research. https://doi.org/10.1007/s00403-025-04306-8

Bhatia, N., et al. (2025). A randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of a nutraceutical supplement in males with thinning hair. Journal of Cosmetic Dermatology. https://doi.org/10.1111/jocd.16778

Brown, L., & Lee, C. (2021). The toxicological effects of fat-soluble vitamins on hair and skin health. Journal of Clinical Dermatology and Nutrition, 13(2), 112–118.

Drake, L., Reyes-Hadsall, S., & Martinez, J. (2023). Evaluation of the safety and effectiveness of nutritional supplements for treating hair loss: A systematic review. JAMA Dermatology. https://doi.org/10.1001/jamadermatol.2022.4867

Drake, M., Patel, R., & Chen, L. (2023). The role of micronutrients in hair health and alopecia management: An integrative review. Clinical Nutrition Updates, 42(3), 201–210.

Gong, Y., Zhao, H., & Li, S. (2023). Association between serum vitamin D levels and alopecia: A population-based observational study. Dermato-Endocrinology, 15(1), 45–53.

InformedHealth.org. (2023). In brief: What is the structure of hair and how does it grow? Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG). Retrieved September 26, 2025, from https://www.ncbi.nlm.nih.gov/books/NBK546248/

Johnson, K., Morales, P., & Tanaka, R. (2023). Drug-induced alopecia: Mechanisms, prevalence, and prevention strategies. International Journal of Trichology, 15(4), 182–189.

Kim, A., et al. (2024). Effect of AP collagen peptides on hair shaft properties. [Journal name unavailable].

Li, S., et al. (2025). Methionine modulates the growth and development of hair papilla cells via Wnt signaling. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms26041495

Li, X., Huang, Q., & Zhang, W. (2023). Vascular endothelial growth factor-mediated angiogenesis in hair follicle regeneration. Experimental Dermatology Research, 19(2), 97–105.

Lippert, H. (2020). Lehrbuch Anatomie. München: Urban und Fischer.

Martin-Biggers, J., Barbosa Bueno de Campos, M. E., et al. (2024). A randomized, placebo-controlled clinical study evaluating a dietary supplement for hair growth. Journal of Clinical and Aesthetic Dermatology.

Martin-Biggers, J., et al. (2024). Randomized, placebo-controlled clinical study of a gummy supplement containing B-vitamins and zinc on hair growth. Nutrients.

Martin-Biggers, J., et al. (2024). Randomized, placebo-controlled clinical study of a gummy supplement on hair growth. Nutrients.

Natarelli, N., et al. (2023). An integrative and mechanistic approach to the hair growth cycle and hair loss. Frontiers in Medicine, 10, 1156. https://doi.org/10.3390/jcm12030893

Shi, L., Han, J., & Park, S. (2024). Growth factor modulation in follicular dermal papilla cells: Implications for hair regeneration. Frontiers in Cell and Developmental Biology, 12, 114568.

Smith, J. A., & Doe, R. B. (2019). Hair follicle regeneration and physiology. Dermatology Review, 22(1), 10–25. https://doi.org/10.1064740618300270

Smith, R., Patel, D., & Young, A. (2022). Nutritional supplementation and hair loss: A systematic review of clinical evidence. Journal of Cosmetic Dermatology, 21(7), 2778–2789.

Wang, L., Gao, F., & Xu, T. (2023). Scalp microbiome diversity and its association with hair health: A metagenomic analysis. Frontiers in Microbiology, 14, 1182445.

Wang, X., et al. (2024). The role of linoleic acid in skin and hair health: A review. Nutrients. https://doi.org/10.3390/ijms26010246

Westgate, G. E., et al. (2025). Hair longevity—Evidence for a multifactorial holistic approach. Journal of Clinical Medicine. https://doi.org/10.3390/jcm14061894

Wiley Journal of Cosmetic Dermatology. (2025). Randomized, double-blind, placebo-controlled study of a nutraceutical in men with thinning hair. Journal of Cosmetic Dermatology.

Xie, J., Liu, M., & Chen, Z. (2022). Molecular mechanisms and extrinsic factors regulating hair follicle cycling and growth. International Journal of Molecular Sciences, 23(18), 10365.

Yano, K., Brown, L. F., & Detmar, M. (2001). Control of hair growth and follicle size by VEGF-mediated angiogenesis. Journal of Clinical Investigation, 107(4), 409–417. Retrieved September 26, 2025, from https://pmc.ncbi.nlm.nih.gov/articles/PMC199257/ https://doi.org/10.1172/JCI11317

Yelich, A., et al. (2024). Biotin for hair loss: Teasing out the evidence. [Journal name unavailable].

Zhou, Q., Zhang, T., & Lin, Y. (2024). Clinical evaluation of concentrated growth factor injection in patients with androgenetic alopecia: A prospective randomized trial. Dermatologic Therapy, 37(2), e15974.

Downloads

Published

2025-10-30

How to Cite

Nabila Ayu Imani, Hapsari Triandriyani, & Hadi Firmansyah S. (2025). Peran Multivitamin terhadap Pertumbuhan dan Kesehatan Rambut: Literature Review. Jurnal Ilmiah Kedokteran Dan Kesehatan, 5(1), 441–449. https://doi.org/10.55606/klinik.v5i1.5699