Identifikasi Drug Related Problems Potensial Kategori Interaksi Obat pada Pasien Hipertensi di RSU Royal Prima Medan
DOI:
https://doi.org/10.55606/klinik.v5i2.6448Keywords:
Comorbidities, DRPs, Drug Interactions, Hypertension, Medication UseAbstract
Hypertension is a disease whose prevalence continues to increase from year to year, and the success of its therapy is largely determined by the appropriateness of drug selection and use. Treatment failure may occur when the chosen and administered medications do not match the patient’s condition, particularly when accompanied by drug-related problems (DRPs). Poorly controlled hypertension can lead to complications such as heart disease, kidney failure, and stroke. This study aims to identify DRPs among hypertensive patients with or without comorbidities, assessed in terms of the use of medications without indications, indications without medications, excessive dosage, insufficient dosage, and drug interactions. This research is a descriptive, non-experimental study employing a cross-sectional design with retrospective data collection among hypertensive patients with or without comorbidities at RSU Royal Prima Medan during the January–June 2025 period. The sample was selected using purposive sampling based on the inclusion criteria, resulting in a total of 135 patients.
References
Alwin, N., Novriani, E., & Pratama, I. H. (2024). Identifikasi resiko drug related problems (DRPs) pada pasien geriatri dengan penyakit hipertensi di instalasi rawat jalan Rumah Sakit Umum Royal Prima Medan. Jurnal Kesehatan Tambusai, 5(3). https://doi.org/10.31004/jkt.v5i3.32723
Calvo Barbado, D. M., Saiz Fernández, L. C., Leache Alegría, L., Celaya Lecea, M. C., & Gutiérrez-Valencia, M. (2022). Acute Kidney Injury associated with "Triple whammy" combination: a protocol for a systematic review. F1000Research, 11, 496. https://doi.org/10.12688/f1000research.109987.2
DiPiro, J. T., Yee, G. C., & Posey, L. M. (2020). Pharmacotherapy: A Pathophysiologic Approach, Eleventh Edition. McGraw Hill Professional.
JBT Review Group. (2025). Review article: Drug-related problems in hypertensive patients — Types, causes, and interventions. Jurnal Basic and Translational (JBT). https://jurnalfkip.unram.ac.id/index.php/JBT/article/view/11407
Journal of Pharmacy and Science. (2025). Evaluasi Drug Related Problems (DRPs) pada pasien hipertensi di Rumah Sakit Muhammadiyah Lamongan. Journal of Pharmacy and Science, 10(1). https://www.researchgate.net/publication/393253301
Kusumawardani, L. A., Andrajati, R., & Nusaibah, A. (2020). Drug-related problems in hypertensive patients: A cross-sectional study from Indonesia. Journal of Research in Pharmacy Practice, 9(3), 140–147. https://doi.org/10.4103/jrpp.JRPP_20_16
Kusumiati, M., Christiani, G. J., & Atmaja, S. P. (2024). Evaluasi drug related problems (DRPs) pada pasien hipertensi primer di Puskesmas Depok II Kalasan Sleman. Jurnal Farmamedika (Pharmamedica Journal), 9(1), 16–22. https://doi.org/10.47219/ath.v9i1.319
Rahmi, S., Banne, Y., Anggriani, A., Gultom, E. D., Gurning, S. H., Surbakti, C. I., Brata, A., dkk. (2025). Interaksi obat (L. O. Alifariki, Ed.). Kendari : Progres Ilmiah Kesehatan.
Ratna T. L., Lal Shrestha, S., Bimali, S., Bhusal, S., & Khadka, P. (2021). Drug-drug Interactions between Hypoglycemic and Non-hypoglycemic Medication in Diabetic Patients with Comorbidities in a Tertiary Care Center: A Descriptive Cross-sectional Study. JNMA; journal of the Nepal Medical Association, 59(243), 1125–1130. https://doi.org/10.31729/jnma.7080
Ridwan, B. A., & Rachmah, I. M. (2023). Hubungan kejadian drug related problems (DRPs) dengan ketercapaian target tekanan darah pasien hipertensi di Puskesmas Lalonggasumeeto. Jurnal Farmasi dan Kesehatan Indonesia, 3(2), 103–113. https://doi.org/10.61179/jfki.v3i2.465
Samodyaning Tyas, N. A., Susanti, I., & Handayani, R. P. (2025). Evaluasi drug related problems (DRPs) pada pasien hipertensi di Rumah Sakit Muhammadiyah Lamongan. Journal of Pharmacy and Science, 10(1). https://www.researchgate.net/publication/393253301
Stikes Buleleng. (2025). Identification of drug related problems (DRPs) in hypertension therapy: Concepts and clinical implications. Jurnal Kesehatan Stikes Buleleng. https://jks.stikesbuleleng.ac.id/index.php/jks/article/download/8/7/205
Strauss, M. H., Hall, A. S., & Narkiewicz, K. (2023). The Combination of Beta-Blockers and ACE Inhibitors Across the Spectrum of Cardiovascular Diseases. Cardiovascular drugs and therapy, 37(4), 757–770. https://doi.org/10.1007/s10557-021-07248-1
Titami, A., & Dewi, N. A. (2024). REVIEW: MEKANISME INTERAKSI OBAT PADA PASIEN LANSIA HIPERTENSI. Jurnal Farmasi SYIFA, 2 (2), 51–55. https://wpcpublisher.com/jurnal/index.php/JFS/article/view/210
Xia, T., Xu, L. L., Guo, P. Y., Shi, W. T., Cheng, Y. Q., & Liu, A. J. (2023). Synergism of amlodipine and telmisartan or candesartan on blood pressure reduction by using SynergyFinder 3.0 and probability sum test in vivo. Pharmacology research & perspectives, 11(2), e01064. https://doi.org/10.1002/prp2.1064
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Jurnal Ilmiah Kedokteran dan Kesehatan

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.




