Pendekatan Biopsikososial dalam Memahami Kesehatan Mental

Tinjauan Literatur

Authors

  • Luluk Hermawati Universitas Sultan Ageng Tirtayasa
  • Yuda Nabella Prameswari Universitas Sultan Ageng Tirtayasa
  • Nur Bebi Ulfah Irawati Universitas Sultan Ageng Tirtayasa
  • Rossa Amelia Universitas Sultan Ageng Tirtayasa
  • Hilizza Awalina Zulfa Universitas Sultan Ageng Tirtayasa
  • Sophie Dwiyanti UIN Syarif Hidayatullah Jakarta

DOI:

https://doi.org/10.55606/klinik.v5i3.6738

Keywords:

Biologic, Biopsychosocial, Mental Health, Psychologic, Social

Abstract

Mental health is a fundamental component of overall health that influences quality of life, productivity, and individuals’ social functioning. The development of mental disorders, such as depression and anxiety disorders, cannot be explained by a single factor; rather, it results from the interaction of multiple multidimensional determinants. This literature review aims to analyze the contribution of biological, psychological, and social factors to mental health based on current scientific evidence. This study employed a systematic narrative review approach. Literature searches were conducted in PubMed and Google Scholar databases using keywords related to mental health and biopsychosocial factors. The inclusion criteria comprised studies involving human populations published between 2015 and 2025 with observational, systematic review, or meta-analysis designs. Data were analyzed narratively to identify consistent patterns of findings. The results indicate that biological factors, such as genetic predisposition, neurotransmitter dysregulation, and medical comorbidities, increase vulnerability to mental disorders. Psychological factors, including coping strategies, emotion regulation, and exposure to stress and trauma, influence individuals’ psychological conditions. Social factors, such as social support, socioeconomic status, work or academic environment, and stigma, also play a significant role. In conclusion, mental health is the result of a dynamic interaction among biological, psychological, and social factors. Therefore, a comprehensive biopsychosocial approach is essential in promotive, preventive, and curative efforts.

Author Biographies

Luluk Hermawati, Universitas Sultan Ageng Tirtayasa

Departemen Biologi Medis, Fakultas Kedokteran dan Ilmu Kesehatan

Yuda Nabella Prameswari, Universitas Sultan Ageng Tirtayasa

Departemen Biologi Medis, Fakultas Kedokteran dan Ilmu Kesehatan

Nur Bebi Ulfah Irawati, Universitas Sultan Ageng Tirtayasa

Departemen Parasitologi, Fakultas Kedokteran dan Ilmu Kesehatan

Rossa Amelia, Universitas Sultan Ageng Tirtayasa

Departemen Fisiologi, Fakultas Kedokteran dan Ilmu Kesehatan

Hilizza Awalina Zulfa, Universitas Sultan Ageng Tirtayasa

Departemen Histologi, Fakultas Kedokteran dan Ilmu Kesehatan

Sophie Dwiyanti, UIN Syarif Hidayatullah Jakarta

Departemen Psikologi dan Konseling, Fakultas Kedokteran 

References

Alawiyah, K., et al. (2025). Biologi sel biomedik dasar: Struktur dan fungsi.

AN, A. R. (2024). Analisis faktor penyebab stres pada mahasiswa dan dampaknya terhadap kesehatan mental. Detector: Jurnal Inovasi Riset Ilmu Kesehatan, 2(4), 11–18.

Annita, A., Silitonga, L. L., Sayekti, F. D. J., Taufiq, M., Hermawati, L., Rosyidah, R. A., & Alifah, A. L. (2025). Dasar-dasar biomedik: Teknologi dan aplikasi dalam kesehatan.

Aqila, Y. N., Prameswari, Y. N., & Friska, D. (2025). Hubungan lama pendidikan dan pengetahuan K3 terhadap kepatuhan mahasiswa kedokteran di laboratorium FKIK Untirta. Journal of Baja Health Science, 5(1), 64–71.

Darifah, S., Hermawati, L., Wulansari, E. R., Fidusia, A. E., Agustianti, E., & Husna, F. A. (2025). Remaja dan gaming: Perkembangan gaya hidup sedentari dan risiko kesehatan. Journal of Health and Physical, 1(3), 38–49. https://doi.org/10.58218/jhp.v1i3.1850

Dewi, Y., Relaksana, R., & Siregar, A. Y. (2021). Analisis faktor socioeconomic status (SES) terhadap kesehatan mental: Gejala depresi di Indonesia. Jurnal Ekonomi Kesehatan Indonesia, 5(2), 3.

Dharmayanti, I., Tjandrarini, D. H., Hidayangsih, P. S., & Nainggolan, O. (2018). Pengaruh kondisi kesehatan lingkungan dan sosial ekonomi terhadap kesehatan mental di Indonesia. Jurnal Ekologi Kesehatan, 17(2), 64–74.

GBD 2019 Mental Disorders Collaborators. (2022). Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990–2019: A systematic analysis for the Global Burden of Disease Study 2019. The Lancet Psychiatry, 9(2), 137–150. https://doi.org/10.1016/S2215-0366(21)00395-3

Hall, L. S., Adams, M. J., Arnau-Soler, A., Clarke, T. K., Howard, D. M., Zeng, Y., … McIntosh, A. M. (2018). Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank. Translational Psychiatry, 8(1), 9. https://doi.org/10.1038/s41398-017-0034-1

Hughes, K., Bellis, M. A., Hardcastle, K. A., Sethi, D., Butchart, A., Mikton, C., Jones, L., & Dunne, M. P. (2017). The effect of multiple adverse childhood experiences on health: A systematic review and meta-analysis. The Lancet Public Health, 2(8), e356–e366. https://doi.org/10.1016/S2468-2667(17)30118-4

Lund, C., Brooke-Sumner, C., Baingana, F., Baron, E. C., Breuer, E., Chandra, P., … Saxena, S. (2018). Social determinants of mental disorders and the Sustainable Development Goals: A systematic review of reviews. The Lancet Psychiatry, 5(4), 357–369. https://doi.org/10.1016/S2215-0366(18)30060-9

McEwen, B. S., & Akil, H. (2020). Revisiting the stress concept: Implications for affective disorders. Journal of Neuroscience, 40(1), 12–21. https://doi.org/10.1523/JNEUROSCI.0733-19.2019

Miller, A. H., & Raison, C. L. (2016). The role of inflammation in depression: From evolutionary imperative to modern treatment target. Nature Reviews Immunology, 16(1), 22–34. https://doi.org/10.1038/nri.2015.5

Mullins, N., Perroud, N., Uher, R., Butler, A. W., Cohen-Woods, S., Rivera, M., … Lewis, C. M. (2014). Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 165B(5), 428–437. https://doi.org/10.1002/ajmg.b.32247

Nugroho, M. R., Prameswari, Y. N., & Abdullah, R. (2025). Hubungan tingkat stres dengan persentase lemak tubuh pada mahasiswa Program Studi Kedokteran Universitas Sultan Ageng Tirtayasa. Ibnu Sina: Jurnal Kedokteran dan Kesehatan, 24(2), 468–481.

Petrykey, K., Lippé, S., Sultan, S., Robaey, P., Drouin, S., Affret-Bertout, L., … Krajinovic, M. (2024). Genetic factors and long-term neurocognitive deficits, anxiety, and depression. Cancer Epidemiology, Biomarkers & Prevention, 33(2), 234–243. https://doi.org/10.1158/1055-9965.EPI-23-0634

Power, R. A., Tansey, K. E., Buttenschøn, H. N., Cohen-Woods, S., Bigdeli, T., Hall, L. S., … Lewis, C. M. (2017). Genome-wide association for major depression. Biological Psychiatry, 81(4), 325–335. https://doi.org/10.1016/j.biopsych.2016.05.010

Prameswari, Y. N. (2025a). Hubungan gangguan mental emosional dengan kecanduan media sosial. Journal of Baja Health Science, 5(1), 114–125.

Prameswari, Y. N. (2025b). Adaptif atau maladaptif? Analisis hubungan mekanisme koping dengan tingkat kecemasan pada remaja. Journal of Baja Health Science, 5(2), 169–186.

Prameswari, Y. N., Delfecio, I., & Darifah, S. (2025). Relationship between mental health and work performance. Diponegoro Medical Journal, 15(1), 1–11.

Rahmawaty, F., Silalahiv, R. P., Berthiana, T., & Mansyah, B. (2022). Faktor-faktor yang mempengaruhi kesehatan mental pada remaja. Jurnal Surya Medika, 8(3), 276–281.

Ranlund, S., Rosa, M. J., de Jong, S., Cole, J. H., Kyriakopoulos, M., Fu, C. H. Y., … Dima, D. (2018). Polygenic risk scores and brain structure. NeuroImage: Clinical, 20, 1026–1036. https://doi.org/10.1016/j.nicl.2018.10.008

Supini, P., Gandakusumah, A. R. P., Asyifa, N., Auliya, Z. N., & Ismail, D. R. (2024). Faktor-faktor yang mempengaruhi kesehatan mental pada remaja. Journal of Education Religion Humanities and Multidisciplinary, 2(1), 166–172.

Sutikno, E. (2017). Faktor-faktor yang berhubungan dengan gangguan kesehatan mental pada lansia.

World Health Organization. (2025, October 8). Mental health: Strengthening our response. https://www.who.int/news-room/fact-sheets/detail/mental-health-strengthening-our-response

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Published

2026-06-04

How to Cite

Hermawati, L., Prameswari, Y. N., Irawati, N. B. U., Amelia, R., Zulfa, H. A., & Dwiyanti, S. (2026). Pendekatan Biopsikososial dalam Memahami Kesehatan Mental: Tinjauan Literatur. Jurnal Ilmiah Kedokteran Dan Kesehatan, 5(3), 01–11. https://doi.org/10.55606/klinik.v5i3.6738