Uji Efek Nefroprotektif Ekstrak Kulit Buah Mangga Arumanis (Mangifera Indica L. ) terhadap Fungsi Ginjal Tikus Putih Jantan yang Diinduksi Rifampisin
DOI:
https://doi.org/10.55606/klinik.v4i1.5149Keywords:
Creatinine, Mangifera Indica L., Nephroprotective, Renal Histopathology, RifampicinAbstract
This study aimed to evaluate the nephroprotective effect of mango peel extract (Mangifera indica L.) on the kidney function of male white rats (Rattus norvegicus) induced by rifampicin. Rifampicin is a first-line antibiotic used to treat tuberculosis, but its repeated use can cause side effects, including nephrotoxicity. This nephrotoxic effect can damage kidney function and disrupt the body's balance. Therefore, the search for agents that can protect the kidneys from damage caused by rifampicin is important. One potential natural nephroprotective agent is mango peel extract, which is known to contain bioactive compounds with antioxidant and anti-inflammatory activities, such as flavonoids, tannins, and saponins. This study was conducted experimentally with five treatment groups. The normal control group was given distilled water, the negative control group was given rifampicin, and three treatment groups were given mango peel extract at doses of 100, 200, and 400 mg/kgBW. The parameters observed included serum creatinine levels in rats before and after treatment, as well as histopathological features of kidney tissue to assess the presence of structural damage to the kidneys. The results showed that rifampicin administration increased serum creatinine levels, indicating impaired kidney function, and caused structural damage to kidney tissue. However, administration of arumanis mango peel extract, especially at a dose of 400 mg/kgBW, significantly reduced serum creatinine levels, approaching normal control values, and improved kidney histological structure. The damage score in kidney tissue in the group given arumanis mango extract also showed significant improvement compared to the negative control group. This nephroprotective effect is thought to be related to the content of bioactive compounds in arumanis mango extract, which have antioxidant and anti-inflammatory activities, which can reduce oxidative stress and inflammation in the kidneys.
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